Allopurinol

SKU: orb1310380

Description

Allopurinol (Zyloric) is a xanthine oxidase inhibitor used to reduce uric acid production. It is widely applied in research on hyperuricemia and gout, serving as a key tool for both in vitro enzymatic assays and in vivo animal model studies.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 315-30-0
• MW: 136.11
• Purity: 99.96% (May vary between batches)
• Formula: C₅H₄N₄O
• SMILES: OC1=NC=NC2=C1C=NN2
• Target: Xanthine Oxidase,ROS
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (3.67 mM);DMSO:16.4 mg/mL (120.49 mM);H2O:Insoluble;Ethanol:3 mg/mL (22.04 mM)

Bioactivity

• Target IC50:
  XO:7.82±0.12 μM
• In Vivo:
  10 mM Allopurinol inhibited the activity of oxygen xanthine oxidase produced by hypoxia-reoxygenation injury.Allopurinol reduced intracellular Ca2+ concentration by enhancing xanthine oxidase activity.Allopurinol reversed the increase in xanthine oxidase activity in neonatal rat hearts with ischemia-reperfusion injury.
• In Vitro:
  10 mM Allopurinol inhibited the activity of oxygen xanthine oxidase produced by hypoxia-reoxygenation injury.Allopurinol reduced intracellular Ca2+ concentration by enhancing xanthine oxidase activity.Allopurinol reversed the increase in xanthine oxidase activity in neonatal rat hearts with ischemia-reperfusion injury.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

hyperuricemia, HIF-1α, HIF-2α, gout, HUVEC cells, orally active, Inhibitor, Lopurin, inhibit, anti-depressant, anti-leishmanial, anti-nociception, Allopurinol, XO, Xanthine Oxidase, XanthineOxidase, Zyloprim, Zyloric

Compound Identifiers

PubChem CID

135401907