Allopurinol riboside

SKU: orb1308870

Description

Allopurinol riboside, a metabolite of allopurinol, exhibits antiparasitic activity. It acts as a competitive inhibitor of purine nucleoside phosphorylase, with a Ki of 277 µM against inosine. This small molecule is used in biochemical research to study purine salvage pathways in parasites, relevant for both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 16220-07-8
• MW: 268.23
• Purity: 99.73% (May vary between batches)
• Formula: C₁₀H₁₂N₄O₅
• SMILES: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ncc2c1nc[nH]c2=O
• Target: Endogenous Metabolite,Drug Metabolite,Parasite
• Solubility: DMSO:95 mg/mL (354.17 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (12.3 mM)

Bioactivity

• In Vivo:
  Low levels of Allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. Probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma. Allopurinol riboside peaks in plasma 1.6 hours after administration, has an elimination half-life of 3 h, and has steady-state concentrations in the therapeutic range.
• In Vitro:
  Allopurinol riboside is effective against parasites including leishmaniasis and American trypanosomiasis. Allopurinol riboside is selectively toxic because it is not metabolized by the corresponding enzymes in humans. Humoral immunity is not suppressed by Allopurinol riboside. Lymphocyte blastogenesis induced by PHA and Con A is significantly suppressed by Allopurinol riboside in a concentration-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Parasite, Inhibitor, Human Endogenous Metabolite, Endogenous Metabolite, EndogenousMetabolite, Allopurinol riboside, DrugMetabolite, Drug Metabolite, Purine nucleoside phosphorylase

CAS: 16220-07-8

Compound Identifiers

PubChem CID

135407110