Allopurinol riboside

SKU: orb1308870

Description

Allopurinol riboside

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 16220-07-8
• MW: 268.23
• Purity: 99.73%
• Formula: C₁₀H₁₂N₄O₅
• SMILES: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ncc2c1nc[nH]c2=O
• Target: Endogenous Metabolite,Parasite,Drug Metabolite
• Solubility: DMSO:95 mg/mL (354.17 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (12.3 mM)

Bioactivity

• In Vivo:
  Low levels of Allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. Probenecid reduce the renal clearance of allopurinol riboside, extend the half-life of allopurinol riboside in plasma, and triple the levels of allopurinol riboside in plasm. Allopurinol riboside peaks in plasma 1.6 hours after administration, has an elimination half-life of 3 h, and has steady-state concentration in the therapeutic rang .
• In Vitro:
  Allopurinol riboside is effective against parasites including leishmaniasis and American trypanosomiasis. Allopurinol riboside is selectively toxic because it is not metabolized b the corresponding enzymes in human. Humoral immunity is not suppressed by Allopurinol riboside. Lymphocyte blastogenesis induced by PHA and Con A is significantly suppressed by Allopurinol riboside in a concentration dependent manne.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

inhibit, Parasite, Inhibitor, Human Endogenous Metabolite, Endogenous Metabolite, EndogenousMetabolite, Allopurinol riboside, DrugMetabolite, Drug Metabolite, Purine nucleoside phosphorylase

CAS: 16220-07-8

Compound Identifiers

PubChem CID

135407110