Allopurinol Sodium

SKU: orb1300822

Description

Allopurinol Sodium is a potent xanthine oxidase inhibitor, exhibiting an IC50 value of 7.82±0.12 µM. This compound is widely used in biochemical research to study purine metabolism, hyperuricemia, and gout-related mechanisms in both in vitro enzymatic assays and in vivo animal models.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 17795-21-0
• MW: 159.1
• Purity: 99.93% (May vary between batches)
• Formula: C₅H₄N₄NaO
• SMILES: [Na+].O=C1NC=NC2=C1C=NN2
• Target: Xanthine Oxidase,ROS
• Solubility: DMSO:30 mg/mL (188.56 mM);Ethanol:2 mg/mL (12.57 mM);H2O:29 mg/mL (182.28 mM)

Bioactivity

• Target IC50:
  XO:7.82±0.12 μM.
• In Vitro:
  EOL-1, human acute myeloid eosinophilic leukemia cell line, was antiproliferative byBI-9564 with EC50 of 800 nM.BRD7 implied as a tumor suppressor and is down-regulated in cancer cells, BI-9564 shows Kd of 73 nM for it, and is >10-fold more selective for BRD9 over the high homologues bromodomain. BI-9564 (<5 μM) shows no activity against 324 kinases, when BI-9564 at 10 μM, an inhibition >40% is observed for only 2 out of 55 GPCRs.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sodium allopurinol, Xanthine Oxidase, XO, Allopurinol, Allopurinol Sodium, Allopurinol sodium salt, anti-depressant, anti-leishmanial, anti-nociception, orally active, inhibit, HIF-2α, HIF-1α, Inhibitor, hyperuricemia, HUVEC cells, gout

Compound Identifiers

PubChem CID

135534565