Allopurinol

SKU: orb1225329

Description

Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.(In Vitro):Allopurinol (0, 10, 100, 1000 μg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells.Allopurinol (0, 10, 100, 1000 μg/ml; 24 h) reduces angiogenesis traits of HUVEC cells.\n(In Vivo):Allopurinol (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse.Allopurinol (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 315-30-0
• MW: 136.11
• Purity: >98% (HPLC)
• Formula: C₅H₄N₄O
• SMILES: C1=C2C(=NC=NC2=O)NN1
• Target: ROS
• Solubility: Ethanol: 3 mg/mL (22.04 mM); Water: 4 mg/mL (29.38 mM); DMSO: 27 mg/mL (198.36 mM)

Bioactivity

• In Vivo:
  Allopurinol (39 mg/kg; p.o. ; daily for 21 successive days) shows anti-depressant activity in mouse. Allopurinol (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse. Animal model: 20-30 g, male Swiss Albino mice. Dosage: 39 mg/kg. Administration: p.o. ; daily for 21 successive days. Result: Reduced the immobility time in the FST with the immobility time of 129.8±10.5 s. Animal model: 30-40 g, male adult Swiss albino mice. Dosage: 10, 50, 100, 200, 400 mg/kg. Administration: i.p. Result: Produced dose-dependent anti-nociception in the tail-flick, hot-plate.
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• In Vitro:
  Allopurinol (0, 10, 100, 1000 μg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells. Allopurinol (0, 10, 100, 1000 μg/ml; 24 h) reduces angiogenesis traits of HUVEC cells. Western blot analysis. Cell line: HFF, HUVEC cells. Concentration: 0, 10, 100, 1000 μg/ml. Incubation time: 17 h. Result: Reduced HIF-1α and HIF-2α protein expression in a dose dependent manner.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Allopurinol | Zyloprim | Lopurin | Zyloric | Allohexal | Allohexan

Quick Database Links

Gene Symbol

ROS