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Ac4ManNAz
Catalog Number: orb1734949
| Catalog Number | orb1734949 |
|---|---|
| Category | Small Molecules |
| Description | The tetraacetylated N-Azidoacetyl-mannosamine (Ac 4ManNAz) provides a non-radioactive alternative for glycoconjugate vi-sualization. It is cell-permeable, intracellularly processed and incorporated instead of its natural monosaccharide counterpart N-Acetylmannosamine(ManNAc). The resulting Azide-functionalized glycoconjugates can subse-quently be detected via Cu(I)-catalyzed or Cu(I)-free Click Chemistry that offers the choice to introduce a Biotin group (via Azides of Biotin or DBCO-containing Biotin, respectively) for subsequent purification tasks or to introduce fluorescent group (via Azides of fluorescent dyes or DBCO-containing fluorescent dyes, respectively) for subsequent microscopic imaging. Recommended concentration for metabolic labeling: 25-75 µM. This concentration range may serve as a starting point for an individual assay set-up. |
| Form/Appearance | oil; Color: off-white to grey |
| Purity | mass identification (ESI-MS) |
| MW | Theoretical MW: 430.37 g/mol; Detected MW: 430.13 g/mol |
| Application notes | Glycoconjugate synthesis monitoring by metabolic labeling. |
| Solubility (25°C) | DMSO, DMF, MeOH |
| CAS Number | 361154-30-5 |
| Formula | C16H22N4O10 |
| SMILES | [C@H]1([C@@H](C(O[C@@H]([C@H]1OC(=O)C)COC(=O)C)OC(=O)C)NC(=O)CN=[N+]=[N-])OC(=O)C |
| Storage | store at -20 °C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Ac4ManNAz [orb532361]
mass identification (ESI-MS)
361154-30-5
Theoretical MW: 430.37 g/mol; Detected MW: 430.13 g/mol
C16H22N4O10
100 mgAc4ManNAz [orb1220165]
>98% (HPLC)
361154-30-5
430.4
C₁₆H₂₂N₄O₁₀
5 mg, 25 mg, 50 mg, 100 mg, 10 mg, 1 g, 500 mg, 200 mg, 2 mgAc4ManNAz [orb1308698]
98.42%
361154-30-5
430.37
C16H22N4O10
2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)Ac4ManNAz [orb1734948]
mass identification (ESI-MS)
361154-30-5
Theoretical MW: 430.37 g/mol; Detected MW: 430.13 g/mol
C16H22N4O10
5 mg
For example, if the dosage of your experiment is 10mg/kg, the weight of each animal is 50g, and the volume of the dosing is 100μL, then the working solution concentration of your experiment is 5mg/mL. If the formula you used is 5% DMSO+ 30% PEG300+ 5% Tween 80 + 60% Saline/PBS/ddH2O, the preparation method is as follows:
Mother liquor preparation method: 5mg of drug dissolved in 100μL DMSO (mother liquor concentration is 50mg/mL). Preparation method of in vivo formulation: For 1mL of working solution preparation, take 50μL of DMSO mother liquor, add 300 μL of PEG300 to mix well and clarify, then add 50μL of Tween-80 to mix well and clarify, and finally add 600μL of Saline/PBS/ddH2O to mix well and clarify.Note:
- For Reference Only. Please choose the appropriate dissolution protocol according to your experimental animal and administration method.
- We suggest that in cell experiments, the final concentration of DMSO is not more than 0.1%, in animal experiments, for healthy mice, the final concentration of DMSO is not more than 10%; For nude or frail mice, the final concentration of DMSO is not more than 2%.
