A 83-01

SKU: orb1223680

Description

A potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively; dispalys weak or no inhibitory activity again transcriptional activity of ALK6 and ALK1/2/3; prevents phosphorylation of Smad2/3 and the growth inhibition induced by TGF-beta with no effects on BMP signaling, ERK and p38 MAPK.

Key Properties

• CAS Number: 909910-43-6
• MW: 421.5168
• Purity: >98% (HPLC)
• Formula: C₂₅H₁₉N₅S
• SMILES: S=C(N1N=C(C2=NC(C)=CC=C2)C(C3=CC=NC4=CC=CC=C34)=C1)NC5=CC=CC=C5
• Target: TGFBR
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  A 83-01 (GMP) (human foreskin fibroblast with aMHC-GFP; incubates in vitro 6 days than transplanted into the infarcted hearts of immunodeficient mice) induces fibroblasts converts into cardiomyocyte-like cells in infarcted mouse heart.
• In Vitro:
  A 83-01 (GMP) induces human foreskin fibroblasts converts into ardiomyocyte-like cells a more open-chromatin conformation at key heart developmental genes. A 83-01 (GMP) induces cord blood or fetal liver-derived CD34+ cells converts into pluripotent cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A83-01 | A-83-01

Quick Database Links

Gene Symbol

TGFBR