(Z)-Guggulsterone

SKU: orb1307594

Description

(Z)-Guggulsterone induces apoptosis in human prostate cancer cells and exhibits anti-angiogenic properties by inhibiting the VEGF-VEGFR2-Akt signaling pathway. This small molecule is utilized in oncology research for studying cell proliferation and tumor angiogenesis in both in vitro and in vivo models.

Research Area

Cardiovascular Research, Cell Biology, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 39025-23-5
• MW: 312.45
• Purity: 99.72%
• Formula: C₂₁H₂₈O₂
• SMILES: C\C=C1/C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
• Target: Apoptosis,SARS-CoV,FXR,Angiotensin-converting Enzyme (ACE),Akt,VEGFR
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  In tumor volume and wet tumor weight, Z-guggulsterone (p.o.; 1 mg; 5 times/week) causes a statistically significant reduction .
• In Vitro:
  In HUVEC, Z-guggulsterone (10, 20 μM; 24 or 48 hours) induces a reduction in the level of VEGF-R2 protein .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(Z) Guggulsterone, (Z)Guggulsterone, (Z)-Guggulsterone, Akt, Apoptosis, Inhibitor, Guggulsterone, inhibit, PKB, Protein kinase B, Vascular endothelial growth factor receptor, VEGF-R2, VEGFR

Compound Identifiers

PubChem CID

6450278