Guggulsterone (Z-)

SKU: orb1307594

Description

(Z)-Guggulsterone induces apoptosis in human prostate cancer cells and exhibits anti-angiogenic properties by inhibiting the VEGF-VEGFR2-Akt signaling pathway. This small molecule is utilized in oncology research for studying cell proliferation and tumor angiogenesis in both in vitro and in vivo models.

Research Area

Immunology & Inflammation, Neuroscience, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 39025-23-5
• MW: 312.45
• Purity: >98%
• Formula: C₂₁H₂₈O₂
• SMILES: C\C=C1/C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
• Target: Transcription factor
• Solubility: Soluble in DMSO (up to 6 mg/ml with warming) or in Ethanol (up to 3 mg/ml with warming)

Bioactivity

• In Vivo:
  In tumor volume and wet tumor weight, Z-guggulsterone (p.o.; 1 mg; 5 times/week) causes a statistically significant reduction .
• In Vitro:
  In HUVEC, Z-guggulsterone (10, 20 μM; 24 or 48 hours) induces a reduction in the level of VEGF-R2 protein .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(Z) Guggulsterone, (Z)Guggulsterone, (Z)-Guggulsterone, Akt, Apoptosis, Inhibitor, Guggulsterone, inhibit, PKB, Protein kinase B, Vascular endothelial growth factor receptor, VEGF-R2, VEGFR

Compound Identifiers

PubChem CID

6450278