(Z)-Guggulsterone

SKU: orb1307594

Description

(Z)-Guggulsterone

Research Area

Cardiovascular Research, Cell Biology, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 39025-23-5
• MW: 312.45
• Purity: 99.72%
• Formula: C₂₁H₂₈O₂
• SMILES: C\C=C1/C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
• Target: VEGFR,FXR,SARS-CoV,Akt,Angiotensin-converting Enzyme (ACE),Apoptosis
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  In tumor volume and wet tumor weight, Z-guggulsterone (p.o.; 1 mg; 5 times/week) causes a statistically significant reduction.
• In Vitro:
  In HUVEC, Z-guggulsterone (10, 20 μM; 24 or 48 hours) induces a reduction in the level of VEGF-R2 protein.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

(Z) Guggulsterone, (Z)Guggulsterone, (Z)-Guggulsterone, Akt, Apoptosis, Inhibitor, Guggulsterone, inhibit, PKB, Protein kinase B, Vascular endothelial growth factor receptor, VEGF-R2, VEGFR

Compound Identifiers

PubChem CID

6450278