(Z)-Guggulsterone

SKU: orb1218073

Description

(Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.

Key Properties

• CAS Number: 39025-23-5
• MW: 312.45
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₈O₂
• SMILES: C/C=C/1\C(=O)C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C
• Target: Akt
• Solubility: DMSO:10 mg/mL (32.01 mM; ultrasonic and warming and heat to 60°C)

Bioactivity

• In Vivo:
  Animal model: Male nude mice(5–6 weeks old) s. c. implanted with DU145 cell-containing Matrigel plugs. Dosage: 1 mg. Administration: Oral; 5 times/week. Result: Resulted in a statistically significantly decrease in tumor volume and wet tumor weight.
• In Vitro:
  Western blot analysis. Cell line: Vascular endothelial growth factor (VEGF). Concentration: 10, 20 μM. Incubation time: 24 or 48 hours. Result: Caused a decrease in the level of VEGF-R2 protein in HUVEC.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Akt