Guggulsterone E&Z

SKU: orb1220857

Description

Guggulsterone E&Z is a 3-hydroxy steroid. It has a role as an androgen.

Key Properties

• CAS Number: 95975-55-6
• MW: 312.4
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₈O₂?
• SMILES: [H][C@@]12CC(=O)C(=CC)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
• Target: Akt
• Solubility: DMSO:20.83 mg/mL (66.67 mM）

Bioactivity

• In Vivo:
  Animal model: Wild-type mice with TNBS-induced colitis. Dosage: 100 mg/kg. Administration: Orally; once per day; for 8 days. Result: Improved the survival rates of wild-type mice with TNBS-induced colitis.
  Read more...
• In Vitro:
  Western blot analysis. Cell line: RAW 264.7 murine macrophage cells Concentration: 0.5, 5, 10, 20 μM Incubation time: 24 hours. Result: Suppressed TREM-1, TLR4, and TNF-α expression as well as the phosphorylation of IκBα and NF-κB p65 by LPS.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Akt