YKL-5-124

SKU: orb1305905

Description

YKL-5-124 is a covalent, highly selective CDK7 inhibitor with an IC50 of 9.7 nM against the CDK7/Mat1/CycH complex, demonstrating over 130-fold selectivity versus CDK2 and CDK9. It is a valuable chemical probe for studying transcriptional regulation and cell cycle progression in cancer research models, both in vitro and in vivo.

Research Area

Cell Biology

Key Properties

• CAS Number: 1957203-01-8
• MW: 515.61
• Purity: 99.50% (May vary between batches)
• Formula: C₂₈H₃₃N₇O₃
• SMILES: CN(C)C[C@@H](NC(=O)N1Cc2c(NC(=O)c3ccc(NC(=O)C=C)cc3)n[nH]c2C1(C)C)c1ccccc1
• Target: CDK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.7 mM);DMSO:220 mg/mL (426.68 mM)

Bioactivity

• Target IC50:
  CDK9:3020 nM|CDK2:1300 nM|CDK7:53.5 nM|CDK7-CyclinH-MAT1:9.7 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, irreversible, inhibit, arrest, covalent, CDK, CDK7/Mat1/CycH, CDK7/Cyclin H/MAT1, CDK7, cell-cycle, Cyclin dependent kinase, YKL5124, YKL-5-124, YKL 5 124, Pol-II, T-loop, phosphorylation, transcription

Compound Identifiers

PubChem CID

121443990