YKL-5-124 TFA

SKU: orb1983579

Description

YKL-5-124 TFA, a potent and selective irreversible covalent inhibitor of CDK7, demonstrates IC50 values of 53.5 nM for CDK7 and 9.7 nM for the CDK7/Mat1/CycH complex. It exhibits over 100-fold selectivity for CDK7 over CDK9 and CDK2, while showing no activity against CDK12 and CDK13. This compound effectively induces cell-cycle arrest, inhibits E2F-driven gene expression, and has minimal impact on the phosphorylation status of RNA polymerase II.

Key Properties

• CAS Number: 2748220-93-9
• MW: 629.63
• Formula: C₃₀H₃₄F₃N₇O₅
• SMILES: C(C(O)=O)(F)(F)F.N(C(=O)C1=CC=C(NC(C=C)=O)C=C1)C=2C3=C(C(C)(C)N(C(N[C@H](CN(C)C)C4=CC=CC=C4)=O)C3)NN2
• Target: CDK,Others

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK,Others