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YHO-13177

SKU: orb1223674

Description

YHO-13177 is a acrylonitrile derivative and active form of YHO-13351 that can specifically reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo; reverses BCRP-mediated acquired resistance to SN-38 in A549 cells without cytotoxicity, also shows no effect on P-glycoprotein-mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells and multidrug resistance-related protein 1-mediated doxorubicin resistance in MRP1-transfected human epidermoid cancer KB-3-1 cells.

Images & Validation

Key Properties

CAS Number912287-56-0
MW370.4653
Purity>98% (HPLC)
FormulaC20H22N2O3S
SMILESN#C/C(C1=CC=C(OC)C(OC)=C1)=C\C2=CC=C(N3CCC(O)CC3)S2
TargetBCRP
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

YHO13177

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Protocol Information

YHO-13177 (orb1223674)

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200 mg
500 mg
5 mg
$ 130.00
10 mg
$ 180.00
25 mg
$ 320.00
50 mg
$ 470.00
100 mg
$ 720.00