YHO-13351 free base

SKU: orb1708203

Description

YHO-13351 free base is a water-soluble prodrug that is metabolized to the active BCRP inhibitor YHO-13177. This compound is used in research to study BCRP-mediated drug efflux and resistance in cancer, applicable in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 912288-64-3
• MW: 483.62
• Purity: >99.99% (May vary between batches)
• Formula: C₂₆H₃₃N₃O₄S
• SMILES: CCN(CC)CC(=O)OC1CCN(CC1)c1ccc(\C=C(/C#N)c2ccc(OC)c(OC)c2)s1
• Target: BCRP
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.82 mM);DMSO:90 mg/mL (186.1 mM)

Bioactivity

• In Vivo:
  In mice, YHO-13351 was rapidly converted into YHO-13177 after its oral or intravenous administration. Coadministration of Irinotecan Hydrochloride with YHO-13351 significantly increased the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model, whereas Irinotecan Hydrochloride alone had little effect in these tumor models.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

YHO 13351, YHO 13351 free base, YHO13351, YHO-13351, YHO13351 free base, YHO-13351 free base, BCRP

Compound Identifiers

PubChem CID

11964785