yangonin

SKU: orb1222163

Description

Yangonin is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. Yangonin could be a valuable candidate for the intervention of NF-κB-dependent pathological conditions such as inflammation.(In Vitro):Yangonin is one of the six major kavalactones found in Piper methysticum.Yangonin potently inhibits NF-κB activation through suppression of the transcriptional activity of the RelA/p65 subunit of NF-κB. Yangonin significantly inhibits the induced expression of the NF-κB-reporter gene. However, Yangonin does not interfere with TNF-α-induced inhibitor of κBα (IκBα) degradation, p65 nuclear translocation, and DNA-binding activity of NF-κB. Yangonin inhibits not only the induced NF-κB activation by overexpression of RelA/p65, but also transactivation activity of RelA/p65. Yangonin does not inhibit TNF-α-induced activation of p38, but it significantly impairs activation of ERK 1/2 and stress-activated protein kinase/JNK.

Key Properties

• CAS Number: 500-62-9
• MW: 258.27
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₄O₄
• SMILES: COC1=CC=C(C=C1)C=CC2=CC(=CC(=O)O2)OC
• Target: AChR
• Solubility: In Vitro: DMSO : 25 mg/mL (96.80 mM)

Bioactivity

• In Vitro:
  Yangonin is one of the six major kavalactones found in Piper methysticum. Yangonin potently inhibits NF-κB activation through suppression of the transcriptional activity of the RelA/p65 subunit of NF-κB. Yangonin significantly inhibits the induced expression of the NF-κB-reporter gene. However, Yangonin does not interfere with TNF-α-induced inhibitor of κBα (IκBα) degradation, p65 nuclear translocation, and DNA-binding activity of NF-κB. Yangonin inhibits not only the induced NF-κB activation by overexpression of RelA/p65, but also transactivation activity of RelA/p65. Yangonin does not inhibit TNF-α-induced activation of p38, but it significantly impairs activation of ERK 1/2 and stress-activated protein kinase/JNK.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

AChR