Desmethoxyyangonin

SKU: orb1301325

Description

Desmethoxyyangonin (5,6-Dehydrokavain) demonstrates hepatoprotective effects against LPS or LPS/D-GalN-induced injury in cellular and animal models by modulating IKK/NFκB and Jak2/STAT3 pathways. It also induces CYP3A23 expression, potentially via PXR-independent mechanisms, making it a useful research tool for studying inflammation and drug metabolism.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 15345-89-8
• MW: 228.24
• Purity: 99.61%
• Formula: C₁₄H₁₂O₃
• SMILES: COc1cc(\C=C\c2ccccc2)oc(=O)c1
• Target: NO Synthase,STAT,Monoamine Oxidase,Cytochromes P450,IκB/IKK,JAK
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (8.76 mM);DMSO:45 mg/mL (197.16 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Desmethoxyyangonin, Desmethoxy yangonin, Demethoxyyangonin, 5,6-Dehydrokavain, Inhibitor, MAO, Monoamine Oxidase, MonoamineOxidase, inhibit

Compound Identifiers

PubChem CID

5273621