FAK inhibitor 14

SKU: orb1300054

Description

Y15 (1,2,4,5-Benzenetetramine tetrahydrochloride) is a specific small-molecule inhibitor targeting FAK scaffolding to block its autophosphorylation. It has demonstrated efficacy in suppressing tumor growth in both cellular assays and animal models, making it a valuable tool for cancer research.

Research Area

Cardiovascular Research

Key Properties

• CAS Number: 4506-66-5
• MW: 284.02
• Purity: >98%
• Formula: C₆H₁₀N₄ · 4HCl
• SMILES: Cl.Cl.Cl.Cl.Nc1cc(N)c(N)cc1N
• Target: Kinase
• Solubility: Soluble in DMSO (up to 20 mg/ml) or in Water (up to 15 mg/ml).

Bioactivity

• In Vitro:
  Y15 inhibited viability in thyroid cancer cell lines in a dose-dependent manner.
• Cell Research:
  Apoptosis assay was done with PE Annexin V Apoptosis Detection Kit (BD) to identify apoptotic nuclei. One hundred millimeter plates were seeded with TPC1, K1, BCPAP and TT cells at a concentration of 1 × 10^6 cells in normal growth media. After overnight incubation, plates were treated with one of several doses of Y15 or left untreated. After another 24 h of incubation, cells were collected with trypsin, and following centrifugation, were washed with 1× PBS. Again, cells were centrifuged, PBS was removed and cells were resuspended in binding buffer and filtered through BD mesh tubes. Annexin V and 7-AAD were added to the solution, vortexed and incubated for 15 minutes in the dark. Binding buffer was added and the cells were analyzed by flow cytometry within 1 hour.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Y15

Compound Identifiers

PubChem CID

78260