AZ 3146

SKU: orb1223427

Description

AZ3146 is a novel and potent Mps1 inhibitor, which was used to probe the role of Mps1's catalytic activity during mitosis. AZ3146 also inhibits FAK, JNK1, JNK2, KSP and Kit. In in vitro kinase assays, AZ3146 inhibited human Mps1Cat with an IC50 (50% inhibitory concentration) of ~35 nM. AZ3146 also efficiently inhibited autophosphorylation of full-length Mps1 immunoprecipitated from human cells.

Key Properties

• CAS Number: 1124329-14-1
• MW: 452.55
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₂N₆O₃
• SMILES: COc1c(Nc2ncc3n(C)c(=O)n(C4CCCC4)c3n2)ccc(OC2CCN(C)CC2)c1
• Target: HSV
• Solubility: DMSO : 11.75 mg/mL 25.96 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZ3146 | AZ 3146 | AZ-3146

Quick Database Links

Gene Symbol

HSV