FAK-IN-14

SKU: orb2567323

Description

FAK-IN-14 is a potent and selective small molecule inhibitor of focal adhesion kinase (FAK), also effectively targeting FGFR1 and Pyk2. It induces apoptosis and cell cycle arrest, making it a valuable research tool for studying cancer cell proliferation, migration, and survival in both in vitro and in vivo models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2766666-22-0
• MW: 502.43
• Purity: 99.70% (May vary between batches)
• Formula: C₂₁H₂₄BrN₇OS
• SMILES: O=C(NC)C=1SC=CC1NC2=NC(=NC=C2Br)NC3=CC=C(C=C3)N4CCN(C)CC4
• Target: FGFR,FAK,Akt,c-Kit,mTOR,MEK,PYK2
• Solubility: DMSO:20 mg/mL (39.81 mM)

Bioactivity

• Target IC50:
  FAK:0.2438 nM
• In Vitro:
  FAK-IN-14 is a FAK inhibitor with an IC50 value of 0.2438 nM. it induces U87-MG cells to enter an early apoptotic phase and leads to cycle arrest of these cells in G2/M phase.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mTOR, FGFR1, FAK, FAKIN14, MEK1/2, Akt, cKit, c-Kit, PYK2

Compound Identifiers

PubChem CID

169450787