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VTP50469

SKU: orb1218437

Description

VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.

Images & Validation

Key Properties

CAS Number2169916-18-9
MW630.82
Purity>98% (HPLC)
FormulaC32H47FN6O4S
SMILESCC(C)N(C(C)C)C(=O)C1=C(C=CC(=C1)F)OC2=CN=CN=C2N3CC4(C3)CCN(CC4)CC5CCC(CC5)NS(=O)(=O)C
TargetApoptosis
SolubilityDMSO:125 mg/mL (198.15 mM; Need ultrasonic)

Bioactivity

In Vivo
Animal model: Unconditioned immunodeficient (NSG) mice with MV4; 11 cells. Dosage: 15 mg/kg, 30 mg/kg, and 60 mg/kg. Administration: Oral administration; twice a day; for 28 days. Result: Was highly efficacious across all dosage levels and all treatment groups had a significant survival advantage over the control group.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

VTP50469 (orb1218437)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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Available Sizes

Select a size below

500 mg
5 mg
$ 510.00
10 mg
$ 790.00
25 mg
$ 1,260.00
50 mg
$ 1,680.00
100 mg
$ 2,270.00
200 mg
$ 3,050.00