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Vinorelbine

SKU: orb1224167

Description

Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM; induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8 nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics.Chemotherapeutic Agents Approved.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number71486-22-1
MW778.9323
Purity>98% (HPLC)
FormulaC45H54N4O8
SMILESCCC1=C[C@H]2C[C@@](C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC
TargetMicrotubule/Tubulin
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

KW-2307

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Protocol Information

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100 mg
200 mg
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10 mg
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