Vinorelbine ditartrate

SKU: orb1300974

Description

Vinorelbine ditartrate (KW-2307) is a semi-synthetic vinca alkaloid that acts as an anti-mitotic agent, disrupting microtubule dynamics to inhibit tumor cell proliferation and induce apoptosis. It is widely used in cancer research, demonstrating activity in both in vitro cytotoxicity assays and in vivo xenograft models for various malignancies.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 125317-39-7
• MW: 1079.11
• Purity: 99.93% (May vary between batches)
• Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆
• SMILES: O[C@H]([C@@H](O)C(O)=O)C(O)=O.O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCC1=CC2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC
• Target: Microtubule Associated,Autophagy
• Solubility: H2O:107.9 mg/mL (99.99 mM);DMSO:127 mg/mL (117.69 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (4.63 mM)

Bioactivity

• Target IC50:
  Antimitotic:1.25 nM
• In Vivo:
  METHODS: To assay antitumor activity in vivo, vinorelbine ditartrate (1-10 mg/kg, i.v.) and DT-13 (1.25 mg/kg, by gavage) were administered to BALB/c athymic nude mice bearing NCI-H460 xenografts once daily for three weeks. RESULTS: Treatment with Myricetin or cisplatin alone moderately inhibited tumor growth, but the combination treatment inhibited tumor growth more significantly than Myricetin or cisplatin alone.
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• In Vitro:
  METHODS: Human lung cancer cells NCI-H460 and A549 were treated with Vinorelbine ditartrate (0.01-10 µM) and DT-13 (10 µM) for 48 h. Cell viability was measured by MTT assay. RESULTS: DT-13 significantly increased the cytotoxicity of Vinorelbine on NCI-H460 and A549 cells. The drug-drug interaction between DT-13 and NVB was calculated by combinatorial index (CI) value, which indicated that the DT-13/Vinorelbine combination therapy showed strong synergistic effects in NSCLC cells. METHODS: APC+ or APC- U2OS cells were treated with Vinorelbine ditartrate (1-50 µg/mL) for 4 h. Apoptosis was detected by Flow cytometry. RESULTS: Vinorelbine-induced cell death was more pronounced in APC-deficient cells, suggesting that the number of aCasp3-containing cells increased after 4 h of treatment with a certain concentration of Vinorelbine. This rapid response to Vinorelbine suggests that death is not associated with mitotic arrest.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, inhibit, Inhibitor, Nor-5'-anhydrovinblastine, Nor-5'-anhydrovinblastine ditartrate, Nor-5'-anhydrovinblastine Ditartrate, KW2307, KW-2307, KW 2307, Microtubule/Tubulin, MicrotubuleAssociated, Microtubule Associated, Navelbine tartrate, Navelbine Tartrate, Tubulin, Vinorelbine, Vinorelbine ditartrate, Vinorelbine Ditartrate, Vinorelbine Tartrate

Compound Identifiers

PubChem CID

60779