Vinorelbine ditartrate

SKU: orb1226673

Description

Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM; induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8 nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics.Chemotherapeutic Agents Approved(In Vitro):Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase. Vinorelbine time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner.(In Vivo):After vinorelbine treatment, the first neutropenicepisode occurred after the first (4 dogs), second (1), or sixth(1) vinorelbine treatment in the dogs. Vinorelbine is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m2.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 125317-39-7
• MW: 1079.106
• Purity: >98% (HPLC)
• Formula: C₅₃H₆₆N₄O₂₀
• SMILES: CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O
• Target: Microtubule/Tubulin
• Solubility: DMSO: ≥ 46 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KW-2307 | Nor-5'-anhydrovinblastine ditartrate

Quick Database Links

Gene Symbol

Microtubule/Tubulin