Verubecestat

SKU: orb1300146

Description

Verubecestat (MK-8931) is a potent and selective BACE1 inhibitor. It has been widely used in preclinical in vitro and in vivo research to investigate Alzheimer's disease pathology by modulating amyloid-β peptide production.

Research Area

Neuroscience

Key Properties

• CAS Number: 1286770-55-5
• MW: 409.41
• Purity: 92.24%
• Formula: C₁₇H₁₇F₂N₅O₃S
• SMILES: CN1C(N)=N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
• Target: Beta-Secretase,BACE
• Solubility: Ethanol:5 mg/mL (12.21 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.06 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:81 mg/mL (197.85 mM)

Bioactivity

• Target IC50:
  BACE2:0.37 nM(Ki)|BACE1:1.75 nM(Ki)
• In Vivo:
  Verubecestat(MK-8931) dramatically lowers CSF and cortex Aβ40 in both rats and cynomolgus monkeys following a single oral dose. Due to the 20 h half-life of MK-8931 it is ideal for once-a-day dosing.
• In Vitro:
  Verubecestat(MK-8931) effectively reduces Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Disease, Alzheimer's, Aβ40, b-Secretase, bSecretase, BetaSecretase, Beta-secretase, BACE, BACE1, BACE2, MK8931, MK-8931, MK 8931, orally, inhibit, Inhibitor, βSecretase, β-Secretase, Verubecestat

Compound Identifiers

PubChem CID

51352361