Valsartan

SKU: orb1300528

Description

Valsartan (CGP 48933) is a tetrazole-based, selective angiotensin II type 1 (AT1) receptor antagonist used as an antihypertensive agent. It is widely employed in cardiovascular research, including in vitro receptor binding assays and in vivo models of hypertension and heart failure.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 137862-53-4
• MW: 435.52
• Purity: 99.76% (May vary between batches)
• Formula: C₂₄H₂₉N₅O₃
• SMILES: C(N([C@@H]([C@H](C)C)C(O)=O)C(CCCC)=O)C1=CC=C(C2=C(C=CC=C2)C=3NN=NN3)C=C1
• Target: RAAS
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+90% Corn Oil:2 mg/mL (4.59 mM);DMSO:250 mg/mL (574.03 mM)

Bioactivity

• In Vivo:
  Valsartan is a potent diuretic, ACE inhibitor, calcium antagonist, and β-blocker.Valsartan dose-dependently inhibited vasoconstriction of angiotensin II-induced vasoconstriction and lowered blood pressure in a renin-dependent model of hypertension.
• In Vitro:
  Valsartan is a potent diuretic, ACE inhibitor, calcium antagonist, and β-blocker.Valsartan dose-dependently inhibited vasoconstriction of angiotensin II-induced vasoconstriction and lowered blood pressure in a renin-dependent model of hypertension.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CGP 48933, CGP48933, CGP-48933, Diovan, cytokines, blood, Angiotensin Receptor, angiotensin II receptor, aorta, inhibit, Inhibitor, endothelial, failure, heart, TLR2, pressure, proinflammatory, Tareg, Valsartan

Compound Identifiers

PubChem CID

60846