Sacubitril sodium

SKU: orb1689967

Description

Sacubitril sodium (AHU-377) is a potent neprilysin (NEP) inhibitor with an IC50 of 5 nM. It is widely used in cardiovascular research, particularly in studies of heart failure and hypertension, both in vitro and in animal models, often in combination with valsartan.

Research Area

Metabolism Research

Key Properties

• CAS Number: 149690-05-1
• MW: 433.47
• Purity: 99.97% (May vary between batches)
• Formula: C₂₄H₂₈NNaO₅
• SMILES: CCOC([C@H](C)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1)=O.[Na+]
• Target: Neprilysin
• Solubility: H2O:< 1 mg/mL (insoluble);DMSO:10 mg/mL (23.07 mM)

Bioactivity

• In Vivo:
  In volume-dependent hypertensive rat models, oral administration of Sacubitril sodium (30 and 100 mg/kg) produced a dose-dependent antihypertensive effect in Dahl salt-sensitive (Dahl-SS) rats. In contrast, only modest blood pressure reduction was observed in DOCA-salt rats, despite achieving >95% neprilysin enzyme occupancy at 100 mg/kg, indicating greater sensitivity to neprilysin inhibition in the Dahl-SS model.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AHU 377, AHU377, LCZ696, LCZ 696

Compound Identifiers

PubChem CID

23707568