Sacubitril sodium

SKU: orb1689967

Description

Sacubitril sodium (AHU-377) is a potent neprilysin (NEP) inhibitor with an IC50 of 5 nM. It is widely used in cardiovascular research, particularly in studies of heart failure and hypertension, both in vitro and in animal models, often in combination with valsartan.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 149690-05-1
• MW: 433.4726
• Purity: 99.97% (May vary between batches)
• Formula: C₂₄H₂₈NNaO₅
• SMILES: [Na+].CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C1=CC=CC=C1)NC(=O)CCC([O-])=O
• Target: Neprilysin
• Solubility: H2O:< 1 mg/mL (insoluble);DMSO:10 mg/mL (23.07 mM)

Bioactivity

• In Vivo:
  In volume-dependent hypertensive rat models, oral administration of Sacubitril sodium (30 and 100 mg/kg) produced a dose-dependent antihypertensive effect in Dahl salt-sensitive (Dahl-SS) rats. In contrast, only modest blood pressure reduction was observed in DOCA-salt rats, despite achieving >95% neprilysin enzyme occupancy at 100 mg/kg, indicating greater sensitivity to neprilysin inhibition in the Dahl-SS model.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AHU 377, AHU377, LCZ696, LCZ 696

Compound Identifiers

PubChem CID

23707568