Urolithin A

SKU: orb1300010

Description

Urolithin A

Research Area

Cell Biology, Immunology & Inflammation, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1143-70-0
• MW: 228.2
• Purity: >98%
• Formula: C₁₃H₈O₄
• SMILES: O=C1C2=CC(O)=CC=C2C3=C(O1)C=C(O)C=C3
• Target: Inflammasome
• Solubility: Soluble in DMSO up to 50 mg/ml

Bioactivity

• Target IC50:
  St-T1b cells:39.88 µM|T24 cells:43.9 μM|Caco-2 cells:49 μM|12Z endometriotic cells:40.46 µM|SW620 cells:53.561 μM|CK2:0.39 𝜇M
• In Vivo:
  METHODS: To investigate the effects on Alzheimer's disease (AD), Urolithin A (300 mg/kg, 0.5% carboxymethylcellulose) was administered orally once daily for 14 days to APP/PS1 mouse models. RESULTS: Urolithin A ameliorated cognitive deficits, prevented neuronal apoptosis, and enhanced neurogenesis in APP/PS1 mice.Urolithin A attenuated Aβ deposition and periplaque microglia and astrocyte hyperplasia in the cortex and hippocampus. Urolithin A affects key cell signaling pathways, particularly by enhancing brain AMPK activation, decreasing activation of P65NF-κB and P38MAPK, and inhibiting degradation of Bace1 and APP.
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• In Vitro:
  METHODS: Human colorectal cancer cells SW620 were treated with Urolithin A (0-30 µM) for 24 h. Cell viability was measured by MTT assay. RESULTS: A dose-dependent decrease in proliferation was observed in Urolithin A-treated cells. METHODS: Human colorectal cancer cells HT29, SW480 and SW620 were treated with Urolithin A (20-100 µM) for 48 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: Treatment of CRC cells with different concentrations of Urolithin A resulted in a significant increase in Cyclin B1 and CDK6, suggesting a strong cell cycle accumulation in G2/M phase.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Urolithin A, Reactive Oxygen Species, Endogenous Metabolite, inhibit, Inhibitor, apoptosis, Apoptosis, autophagy, Autophagy, DNA/RNA Synthesis, DNA synthesis, Drug Metabolite

Compound Identifiers

PubChem CID

5488186