Urolithin M5

SKU: orb2567322

Description

Urolithin M5 (Decarboxyellagic acid) is a neuraminidase inhibitor derived from olive leaves, exhibiting antiviral and anticancer properties. This small molecule is a valuable research tool for studying infections caused by influenza A virus and SARS-CoV-2 in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 91485-02-8
• MW: 276.2
• Purity: 95.32%
• Formula: C₁₃H₈O₇
• SMILES: O=C1OC=2C(O)=C(O)C=CC2C3=C(O)C(O)=C(O)C=C13
• Target: Others,Influenza Virus
• Solubility: H2O:15 mg/mL (54.31 mM);DMSO:62 mg/mL (224.48 mM)

Bioactivity

• Target IC50:
  Virus:3.74~16.51 μM|MDCK cells:CC50=227.4 μM
• In Vivo:
  Specific-pathogen-free female BALB/c mice weighing 16 to 18 g. A total of 200 mg/kg/d urolithin M5 treatment improved the survival rate to 50%, which was significantly higher than the vehicle group. These results indicated that 200 mg/kg/d urolithin M5 had a protective effect on PR8-infected mice.
• In Vitro:
  The cytotoxicity of urolithin M5 was initially assessed using the MTT assay on MDCK cells. Urolithin M5 had a CC50 value of 227.4 μM. 25 μM urolithin M5 inhibited all virus growth, urolithin M5 was the most effective compound, with an IC50 ranging from 3.74 to 16.51 μM.

Storage & Handling

• Storage: store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UrolithinM5, Decarboxyellagic acid, neuraminidase(NA)

Compound Identifiers

PubChem CID

18504424