Urolithin C

SKU: orb1296863

Description

Urolithin C is a gut microbial metabolite derived from ellagic acid. It has been shown in vitro to induce apoptosis in PC12 cells via a mitochondria-dependent pathway, making it a compound of interest for neuroscience and cell death research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 165393-06-6
• MW: 244.2
• Purity: 99.53% (May vary between batches)
• Formula: C₁₃H₈O₅
• SMILES: Oc1ccc2c(c1)oc(=O)c1cc(O)c(O)cc21
• Target: ROS,Reactive Oxygen Species,Calcium Channel,IGF-1R,Apoptosis,Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.19 mM);DMSO:64.67 mg/mL (264.82 mM)

Bioactivity

• In Vivo:
  In male Wistar rat, the half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V1/F) is 0.831 L/kg and the steady-state volume of distribution (Vss/F) is 55.6 L/kg after the intraperitoneal administration of Urolithin C (10 mg/kg).
• In Vitro:
  Urolithin C is a glucose-dependent activator of insulin secretion acting by facilitating L-type Ca2+ channel opening and Ca2+ influx into pancreatic β-cells.Urolithin C enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation as shown by higher phosphorylation levels in INS-1 β-cells. Urolithin C stimulates reactive oxygen species (ROS) formation.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-diabetic, Apoptosis, Calcium Channel, Ca2+ channels, Ca channels, CalciumChannel, mitochondria, metabolite, inhibit, IGF1R, Inhibitor, Insulin Receptor, insulin, ERK1/2, EndogenousMetabolite, Endogenous Metabolite, gut-microbial, glucose-dependent, Polyphenols, ReactiveOxygenSpecies, Reactive Oxygen Species, ROS, Urolithin C, β-cells

Compound Identifiers

PubChem CID

60198001