UNC926

SKU: orb1303310

Description

UNC926 is a small molecule inhibitor of the methyl-lysine reader proteins L3MBTL1 (IC50: 3.9 µM) and L3MBTL3. It selectively disrupts the interaction between the L3MBTL1 3xMBT domain and the histone mark H4K20me1 without affecting 53BP1 binding, making it a useful chemical probe for epigenetic and cancer research.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1184136-10-4
• MW: 337.25
• Purity: 97.22%
• Formula: C₁₆H₂₁BrN₂O
• SMILES: Brc1cccc(c1)C(=O)N1CCC(CC1)N1CCCC1
• Target: Epigenetic Reader Domain
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.93 mM);DMSO:37.4 mg/mL (110.9 mM)

Bioactivity

• Target IC50:
  L3MBTL1:3.9 μM(Kd)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3xMBT, methyl-lysine, L3MBTL1, L3MBTL3, H4K20me1, EpigeneticReaderDomain, Epigenetic Reader Domain, UNC 926, UNC926, UNC-926, UNC926 Hydrochloride, UNC-926 Hydrochloride

Compound Identifiers

PubChem CID

61041645