UNC926 hydrochloride

SKU: orb1298268

Description

UNC926 hydrochloride

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1782573-49-2
• MW: 373.72
• Purity: 99.93%
• Formula: C₁₆H₂₂BrClN₂O
• SMILES: O=C(C1=CC=CC(Br)=C1)N2CCC(N3CCCC3)CC2.[H]Cl
• Target: Epigenetic Reader Domain
• Solubility: DMSO:150 mg/mL (401.37 mM)

Bioactivity

• Target IC50:
  L3MBTL3:3.2 μM|L3MBTL4:15.6 μM|L3MBTL1:3.9 μM
• In Vitro:
  UNC926 demonstrates a low micromolar affinity toward L3MBTL3, exhibiting an IC50 of 3.2 μM, and shows diminished affinity for other MBT domains without binding to CBX7. In a concentration-dependent manner ranging from 1-25 μM, UNC926 effectively inhibits the interaction between the 3xMBT domain and H4K20me1 and impedes the association of L3MBTL1's 3xMBT with specific histone peptides. However, it does not disrupt the binding of 53BP1 to H4K20me1, indicating that UNC926 specifically targets L3MBTL1 rather than 53BP1.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, methyl-lysine, Epigenetic Reader Domain, EpigeneticReaderDomain, H4K20me1, Inhibitor, L3MBTL3, L3MBTL4, L3MBTL1, 3xMBT, UNC 926, UNC 926 Hydrochloride, UNC926, UNC926 hydrochloride, UNC926 Hydrochloride, UNC-926 hydrochloride, UNC-926 Hydrochloride, UNC-926

Compound Identifiers

PubChem CID

90488947