Queens' Awards Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

UNC926 hydrochloride

SKU: orb1218620

Description

UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.

Images & Validation

Key Properties

CAS Number1782573-49-2
MW373.72
Purity>98% (HPLC)
FormulaC16H22BrClN2O
SMILESO=C(C1=CC=CC(Br)=C1)N2CCC(N3CCCC3)CC2.[H]Cl
TargetEpigenetic Reader Domain
SolubilityDMSO:150 mg/mL (444.77 mM)

Bioactivity

In Vitro
UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7.UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

  • UNC926 hydrochloride [orb1298268]

    99.93%

    1782573-49-2

    373.72

    C16H22BrClN2O

    1 mg, 25 mg, 50 mg, 100 mg, 200 mg, 1 ml x 10 mM (in DMSO), 5 mg, 10 mg
  • UNC926 [orb1303310]

    97.22%

    1184136-10-4

    337.25

    C16H21BrN2O

    100 mg, 25 mg, 1 ml x 10 mM (in DMSO), 200 mg, 5 mg, 10 mg, 50 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

UNC926 hydrochloride (orb1218620)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
$ 420.00
10 mg
$ 610.00
25 mg
$ 980.00
50 mg
$ 1,370.00
100 mg
$ 1,840.00
500 mg
$ 3,640.00