Tubulin inhibitor 8

SKU: orb1708310

Description

Tubulin inhibitor 8 is a potent small molecule that suppresses tubulin polymerization (IC50 = 0.73 µM) and potently inhibits the growth of K562 leukemia cells (IC50 = 14 nM). This compound is a valuable chemical tool for investigating cytoskeleton dynamics and anticancer mechanisms in cell-based assays.

Research Area

Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1309925-39-0
• MW: 342.35
• Purity: 99.87% (May vary between batches)
• Formula: C₂₁H₁₄N₂O₃
• SMILES: C(=O)(N1C=2C(OC=3C1=CC=CC3)=CC(C#N)=CC2)C4=CC=C(OC)C=C4
• Target: Microtubule Associated
• Solubility: DMSO:3.43 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  BT-549 cells:8 nM|K562 cells:14 nM|Tubulin polymerization:0.73 μM|451Lu cells:2 nM|DLD-1 cells:9 nM|NCI-H460 cells:15 nM|SKOV3 cells:6 nM|COLO 205 cells:6 nM
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• In Vitro:
  Tubulin inhibitor 8 shows excellent antiproliferative potencies with IC50s of 15, 6, 8, 2, 8, 6, and 9 nM for NCIH460, SKOV3, BT549, 451LU, SW480, COLO-205, and DLD-1 tumor cell lines, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MicrotubuleAssociated, Microtubule Associated, Tubulin, tubulin polymerization, Tubulin inhibitor 8, Tubulin polymerization

Compound Identifiers

PubChem CID

53262871