Mc-MMAE

SKU: orb1307359

Description

Mc-MMAE is a maleimidocaproyl-linked derivative of the potent antimitotic agent monomethyl auristatin E, designed for constructing antibody-drug conjugates (ADCs). It is widely used in oncology research for evaluating ADC efficacy in both in vitro cytotoxicity assays and in vivo xenograft models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 863971-24-8
• MW: 911.18
• Purity: ≥98% (May vary between batches)
• Formula: C₄₉H₇₈N₆O₁₀
• SMILES: CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN1C(=O)C=CC1=O)C(C)C
• Target: Microtubule Associated,PROTAC Linker,Drug-Linker Conjugates for ADC
• Solubility: 10% DMSO+90% Corn Oil:4 mg/mL (4.39 mM);DMSO:51 mg/mL (55.97 mM);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

• In Vitro:
  The production of maleimidocaproyl-MMAE (mc-MMAE) involves introducing maleimidocaproic acid into a dichloromethane solution containing MMAE. This process is then followed by adding diethyl cyanophosphonate and diisopropylethylamine.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Auristatin, DrugLinkerConjugatesforADC, DrugLinker Conjugates for ADC, Drug-Linker Conjugates for ADC, Mc MMAE, Maleimidocaproyl-monomethylauristatin E, McMMAE, Mc-MMAE, Microtubule Associated, MicrotubuleAssociated, Microtubule/Tubulin, Inhibitor, inhibit

Compound Identifiers

PubChem CID

59168780