CRT-0105950

SKU: orb1703576

Description

CRT-0105950 is a potent and selective inhibitor of LIMK1 and LIMK2. It modulates cytoskeletal dynamics by inhibiting cofilin phosphorylation and promoting α-tubulin acetylation in cellular studies, making it a useful pharmacological tool for cancer research, including investigations into renal carcinoma.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1661845-86-8
• MW: 393.89
• Purity: 99.91% (May vary between batches)
• Formula: C₂₁H₁₆ClN₃OS
• SMILES: Cc1ccc(c(Cl)c1)-c1cnccc1-c1cnc(Nc2ccc(O)cc2)s1
• Target: LIM Kinase,Microtubule Associated
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.16 mM);DMSO:100 mg/mL (253.88 mM)

Bioactivity

• Target IC50:
  LIMK2:1 nM|LIMK1:0.3 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LIM Kinase, LIMK2, LIMKinase, LIMK1, Microtubule Associated, MicrotubuleAssociated, CRT 0105950, CRT0105950, CRT-0105950, Tubulin

Compound Identifiers

PubChem CID

117918970