TSC2 (C2) Antibody, Rabbit Polyclonal

SKU: orb67143

Description

Rabbit polyclonal to TSC2.Tuberin (TSC2) forms a complex with TSC1 and inhibits the nutrient-mediated or growth factorstimulatedphosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling.TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of theprotein kinase activity of mTORC1. It is implicated as a tumor suppressor. TSC2 is involved inmicrotubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Defects in TSC2 causetuberous sclerosis type 2 (TSC2) and lymphangioleiomyomatosis (LAM).

Research Area

Cancer, Epigenetics, Infectious Diseases

Images & Validation

• Tested Applications: WB
• Dilution range: WB:1:500-1:1000
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human TSC2
• Molecular Weight: 201
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Disclaimer: For research use only

Alternative Names

anti-TSC2 antibody,anti-Tuberin antibody,anti-Tuberous sclerosis 2 protein antibody,anti-TSC4 antibody

Western blot analysis of total cell extracts from human Hela(Lane1) and mouse MEF(Lane2) using TSC2 antibody

Quick Database Links

UniProt

P49815