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TSC1 (C2) Antibody, Rabbit Polyclonal
Catalog Number: orb67146
| Catalog Number | orb67146 |
|---|---|
| Category | Antibodies |
| Description | Rabbit polyclonal to TSC1.Tuberous sclerosis 1 protein (TSC1) is a peripheral membrane protein. In complex with TSC2, TSC1inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 bynegatively regulating mTORC1 signaling. It seems not to be required for TSC2 GAP activity towardsRHEB. It is implicated as a tumor suppressor. TSC1 is involved in microtubule-mediated proteintransport, but this seems to be due to unregulated mTOR signaling. Defects in TSC1 are the cause oftuberous sclerosis type 1 (TSC1) and may be the cause of focal cortical dysplasia of Taylor ballooncell type (FCDBC). |
| Species/Host | Rabbit |
| Clonality | Polyclonal |
| Tested applications | WB |
| Reactivity | Human |
| Immunogen | C-terminal region of human TSC1 |
| Dilution range | WB:1:1000-1:3000 |
| Purity | Affinity purification |
| Conjugation | Unconjugated |
| MW | 130 |
| UniProt ID | Q92574 |
| Storage | -20°C |
| Buffer/Preservatives | 0.01% NaN3 |
| Alternative names | anti-TSC1 antibody,anti-Hamartin antibody,anti-Tub Read more... |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Western blot analysis of total cell extracts from human Hela(Lane1)
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