TSC1 (C2) Antibody, Rabbit Polyclonal

SKU: orb67146

Description

Rabbit polyclonal to TSC1.Tuberous sclerosis 1 protein (TSC1) is a peripheral membrane protein. In complex with TSC2, TSC1inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 bynegatively regulating mTORC1 signaling. It seems not to be required for TSC2 GAP activity towardsRHEB. It is implicated as a tumor suppressor. TSC1 is involved in microtubule-mediated proteintransport, but this seems to be due to unregulated mTOR signaling. Defects in TSC1 are the cause oftuberous sclerosis type 1 (TSC1) and may be the cause of focal cortical dysplasia of Taylor ballooncell type (FCDBC).

Research Area

Cancer, Epigenetics

Images & Validation

• Tested Applications: WB
• Dilution range: WB:1:1000-1:3000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human TSC1
• Molecular Weight: 130
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Disclaimer: For research use only

Alternative Names

anti-TSC1 antibody,anti-Hamartin antibody,anti-Tuberous sclerosis 1 protein antibody,anti-KIAA0243 antibody,anti-TSC antibody

Western blot analysis of total cell extracts from human Hela(Lane1),human Jurkat(Lane2) and human T47D(Lane3) using TSC1 antibody

Quick Database Links

UniProt

Q92574