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TRPM4-IN-2

SKU: orb2900824

Description

TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number667411-04-3
MW355.77
Purity>98% (HPLC)
FormulaC19H14ClNO4
SMILESO(CC(NC1=C(C(O)=O)C=CC(Cl)=C1)=O)C=2C3=C(C=CC2)C=CC=C3
TargetTRP/TRPV Channel
SolubilityIn Vitro: DMSO : 100 mg/mL (281.08 mM)

Bioactivity

In Vitro
TRPM4-IN-2 (NBA) (50 μM; 0-500 s) blocks the endogenous TRPM4 currents in DU145.Cell Proliferation Assay Cell line: DU145. Concentration: 50 μM. Incubation time: 0-500 s. Result: Blocked 88 ± 9% of the endogenous TRPM4 currents at 50 μM.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information