Trifluoperazine

SKU: orb1298975

Description

Trifluoperazine is a potent dopamine D2 receptor antagonist (IC50 = 1.2 nM) used in schizophrenia research. This phenothiazine neuroleptic is applied in in vitro binding assays and in vivo studies to investigate dopaminergic signaling and antipsychotic mechanisms.

Research Area

Cell Biology, Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 117-89-5
• MW: 407.5
• Purity: 99.98% (May vary between batches)
• Formula: C₂₁H₂₄F₃N₃S
• SMILES: CN1CCN(CCCN2C3=C(SC4=C2C=C(C=C4)C(F)(F)F)C=CC=C3)CC1
• Target: Influenza Virus,CaMK,Adrenergic Receptor,Dopamine Receptor,P-gp,Autophagy
• Solubility: DMSO:242 mg/mL (593.87 mM)

Bioactivity

• Target IC50:
  D2:1.2 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D2, DopamineReceptor, Dopamine, Dopamine Receptor, Beta Receptor, Cluster of differentiation 243, CD243, Calmodulin-dependent kinases, Calmodulin-dependent protein kinases, CaMK, anticancer, antipsychotic, Autophagy, Adrenergic Receptor, AdrenergicReceptor, ABCB1, morphogenesis, InfluenzaVirus, Multidrug resistance protein 1, Influenza Virus, inhibit, Inhibitor, NUPR1, MDR1, schizophrenia, P-glycoprotein, P-gp, Pgp, P-gp (P-glycoprotein), trifluoroperazine, Trifluoperazine

Compound Identifiers

PubChem CID

5566