Trifluoperazine dihydrochloride

SKU: orb1309340

Description

Trifluoperazine dihydrochloride

Research Area

Cell Biology, Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 440-17-5
• MW: 480.43
• Purity: >99.99% (May vary between batches)
• Formula: C₂₁H₂₆Cl₂F₃N₃S
• SMILES: Cl.CN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1
• Target: Influenza Virus,Adrenergic Receptor,CaMK,Dopamine Receptor,P-gp,Autophagy
• Solubility: DMSO:82 mg/mL (170.68 mM);H2O:88 mg/mL (183.17 mM);Ethanol:89 mg/mL (185.25 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.87 mM)

Bioactivity

• Target IC50:
  D2 receptor:1.1 nM
• In Vivo:
  Trifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance.
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• In Vitro:
  Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. Trifluoperazine (< 14.78 mM) suppresses the activities of the mouse splenic NK cell cytotoxicity and the effector-target cell conjugation in a dose dependent manner. Trifluoperazine suppresses interferon-alpha or interleukin-2 induced augmentation of the cytolytic activity of NK cells. Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D2, DopamineReceptor, Dopamine Receptor, Dopamine, Beta Receptor, Cluster of differentiation 243, CD243, anticancer, antipsychotic, Autophagy, Calmodulin-dependent kinases, Calmodulin-dependent protein kinases, CaMK, Adrenergic Receptor, AdrenergicReceptor, ABCB1, inhibit, InfluenzaVirus, Multidrug resistance protein 1, Influenza Virus, Inhibitor, NUPR1, MDR1, morphogenesis, Urinox, P-gp, P-gp (P-glycoprotein), Pgp, P-glycoprotein, schizophrenia, SKF5019, SKF-5019, SKF 5019, Trifluoperazine, Trifluoperazine 2HCl, Trifluoperazine dihydrochloride, Trifluoperazine Dihydrochloride

Compound Identifiers

PubChem CID

2913535