ZZW-115

SKU: orb1685299

Description

ZZW-115 is a Trifluoperazine-derived small molecule that potently inhibits NUPR1 with a Kd of 2.1 µM. It induces tumor regression in vivo via necroptosis and apoptosis, demonstrating research utility in oncology studies without reported neurological side effects.

Research Area

Cell Biology

Key Properties

• CAS Number: 801991-87-7
• MW: 464.59
• Purity: 99.99% (May vary between batches)
• Formula: C₂₄H₃₁F₃N₄S
• SMILES: CN(C)CCN(CC1)CCN1CCCN2C3=C(C=CC(C(F)(F)F)=C3)SC4=CC=CC=C42
• Target: Apoptosis,Others

Bioactivity

• In Vivo:
  Administering ZZW-115 via injection at doses ranging from 0.5 to 5 mg/kg daily for 30 days inhibited growth in pancreatic xenografted tumors in NMRI-Foxn1nu/Foxn1nu (nude) mice implanted with MiaPaCa-2 cells. At a dosage of 5 mg/kg, ZZW-115 treatment in immunocompetent C57BL/6 mice orthotopically implanted with Panc02 cells resulted in a significant reduction of tumor size, rendering it almost unmeasurable in some instances. Notably, tumors ceased to grow a few days post-administration of 5 mg/kg ZZW-115 and exhibited a progressive decrease in size, nearing complete disappearance by the treatment's conclusion.
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• In Vitro:
  ZZW-115, at concentrations ranging from 0.1 to 100 μM and incubation periods between 24 and 72 hours, demonstrates significant anticancer efficacy by effectively killing a variety of cancer cells. It exhibits IC50 values from as low as 0.42 μM in Hep2G cells to 7.75 μM in SaOS-2 cells, indicating its potency across different cell lines including ANOR, HN14, and others . Moreover, ZZW-115 prompts cancer cell death through both necrosis and apoptosis mechanisms, highlighted by increased lactate dehydrogenase (LDH) release and caspase 3/7 activity in treated cells compared to controls. This is further supported by a decrease in ATP production and an overproduction of reactive oxygen species (ROS), showcasing its dual pro-necrotic and pro-apoptotic actions .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ZZW 115, ZZW115, ZZW-115

Compound Identifiers

PubChem CID

25010688