TLR8 agonist 7

• Catalog Number: orb2564585
• Category: Small Molecules
• Description: TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.
• Purity: 98.00%
• MW: 1094.13
• CAS Number: 3034750-26-7
• Formula: C₅₄H₆₃N₉O₁₆
• SMILES: C(NC=1C=C2C(=NC1)CCN(C(OCC3=CC(NC(CNC(CCCCCN4C(=O)C=CC4=O)=O)=O)=C(O[C@@H]5O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)C=C3)=O)C2)(=O)C6(CC6)C=7C=C8C(=CC7)C=C(C(N(CCC)CCO)=O)CC(N)=N8
• Storage: -20°C
• Note: For research use only