TLR7/8 agonist 7d

SKU: orb1738372

Description

TLR7/8 agonist 1 is a dual agonist of Toll-like receptors 7 and 8, exhibiting immunostimulatory properties. It is utilized in research areas including oncology, antiviral studies, and immune-related diseases, with applications in both in vitro cellular assays and in vivo animal models to investigate innate immune activation.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery; Cell Biology

Key Properties

• CAS Number: 1258457-59-8
• MW: 359.47
• Formula: C₂₂H₂₅N₅
• SMILES: N1=C(N)C=2N=C(N(C2C=3C=CC=CC13)CC4=CC=C(C=C4)CN)CCCC
• Target: TLR
• Solubility: DMSO:8 mg/mL (22.25 mM)

Bioactivity

• Target IC50:
  TLR7:20 nM (EC50)
• In Vitro:
  TLR7/8 agonist 1 displays significant immunostimulatory activity. The compound can be directly covalently coupled to commercially available fluorescein isothiocyanate (FITC) and rhodamine B isothiocyanate without significant loss of activity. TLR7/8 agonist 1 retains TLR7 agonist activity with an EC50=20 nM.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CHR-3996, CHR 3996, Nanatinostat, Nanatinostat TFA, Nanatinostat trifluoroacetic acid, Tractinostat, VRx3996, VRx-3996, VRx 3996, TLR7/8 agonist 1, TLR7/TLR8

Compound Identifiers

PubChem CID

52945312