Tauroursodeoxycholate

SKU: orb1305349

Description

UR 906 (Tauroursodeoxycholate) is a hydrophilic tertiary bile acid used in biomedical research. It is applied in studies investigating cholestatic diseases like PBC, metabolic disorders including insulin resistance, and neurodegenerative conditions such as ALS, utilizing both in vitro and in vivo experimental models.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 14605-22-2
• MW: 499.7
• Purity: 98.12% (May vary between batches)
• Formula: C₂₆H₄₅NO₆S
• SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@@H]3O)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(NCCS(=O)(=O)O)=O)C)[H])[H]
• Target: Caspase,ERK,Apoptosis,Endogenous Metabolite,Cytochromes P450
• Solubility: 5% DMSO+95% Saline:4.5 mg/mL (9.01 mM);DMSO:6.25 mg/mL (12.51 mM)

Bioactivity

• In Vivo:
  METHODS: To test the effect on diabetes, Tauroursodeoxycholate (300 mg/kg) was administered intraperitoneally to STZ-induced diabetic C57BL/6 mice once daily for 24 days. RESULTS: After 15 days of treatment, STZ+Tauroursodeoxycholate mice had a 43% reduction in blood glucose compared to the STZ group. This decrease may be due to an increase in insulinemia.
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• In Vitro:
  METHODS: HeLa cells overexpressing the WDR45 mutation were treated with Tauroursodeoxycholate (200 µM) for 24 h, and the expression levels of target proteins were measured by Western Blot. RESULTS: Inhibition of ER stress with Tauroursodeoxycholate significantly reduced the phosphorylation of p38 and LAMP2A as well as the punctate formation of mCherry KFERQ in cells expressing mutant WDR45. METHODS: Undifferentiated neural stem cells NSCs were treated with Tauroursodeoxycholate (100 µM) for 24 h and cell proliferation was detected by Flow cytometry via BrdU. RESULTS: BrdU incorporation increased significantly after incubation with Tauroursodeoxycholate, and Tauroursodeoxycholate regulated cell proliferation. Tauroursodeoxycholate regulates cell proliferation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYP3A, caspase-12, Caspase, caspase-3, Apoptosis, inhibit, molecules, Extracellular signal regulated kinases, ERK, endoplasmic, EndogenousMetabolite, Endogenous Metabolite, Inhibitor, reticulum, stress, Tauroursodeoxycholic Acid, Tauroursodeoxycholate, Taurolite, TUDCA, Ursodeoxycholyltaurine, UR-906, UR906, UR 906

Compound Identifiers

PubChem CID

3034759