Tauroursodeoxycholate sodium

SKU: orb1300279

Description

Tauroursodeoxycholate sodium (TUDC) is a small molecule that inhibits endoplasmic reticulum (ER) stress. It is utilized in research on liver diseases, including cholestasis and cirrhosis, and has demonstrated protective effects in both cellular and animal models of hepatotoxicity.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 35807-85-3
• MW: 521.69
• Purity: 99.78% (May vary between batches)
• Formula: C₂₆H₄₄NNaO₆S
• SMILES: [Na+].CC(CCC(=O)NCCS([O-])(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C
• Target: Endogenous Metabolite,Caspase,ERK,Apoptosis
• Solubility: Ethanol:10 mg/mL (19.17 mM);DMSO:257.5 mg/mL (493.59 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.83 mM);H2O:92 mg/mL (176.35 mM)

Bioactivity

• In Vivo:
  In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations.
• Cell Research:
  Cell lines: Mz-ChA-1 cells. Concentrations: ~200 μM. Method: After trypsinization,Mz-ChA-1 cells are suspended in CCM at 5×104 cells/mL,and 200 μL of the cell suspension is seeded into 96-well plates.After an initial incubation step of 4 h at 37°C in a 5% CO2 incubator,the cells are incubated at 37°C with TUDCA (0.2–200 μM).After incubation for 24–96 h,[3H]thymidine is put into each well at 5.0 μCi/mL and incubated for additional 4 h.[3H]thymidine incorporation is measured by a scintillation counter.
• Animal Research:
  Animal Models: Phalloidin-induced cholestasis ratsFormulation & . Dosages: Saline; 360 μMol/kg. Administration: intravenous injection

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, molecules, Inhibitor, ERK, endoplasmic, Extracellular signal regulated kinases, Caspase, caspase-3, caspase-12, Apoptosis, UR906, UR-906, UR 906, TUDC, TUDCA, Tauroursodeoxycholate, Tauroursodeoxycholate sodium, Tauroursodeoxycholic acid, Tauroursodeoxycholic acid sodium, Tauroursodeoxycholic acid sodium salt, stress, Sodium tauroursodeoxycholate, Sodium Tauroursodeoxycholate, Sodium Tauroursodeoxycholate (TUDC), reticulum

Compound Identifiers

PubChem CID

23664006