Sulfuretin

SKU: orb1297199

Description

Sulfuretin

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 120-05-8
• MW: 270.24
• Purity: >99.99% (May vary between batches)
• Formula: C₁₅H₁₀O₅
• SMILES: Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(O)c(O)c1
• Target: NF-κB,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.4 mM);DMSO:10 mM;Methanol:1 mg/mL (3.7 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  In this study, we investigated the protective effects of Sulfuretin against tert-butyl hydroperoxide (t-BHP)-induced oxidative injury. The results indicated that the addition of Sulfuretin before t-BHP treatment significantly inhibited cytotoxicity and reactive oxygen species (ROS) production in human liver-derived HepG2 cells. Sulfuretin up-regulated the activity of the antioxidant enzyme heme oxygenase (HO)-1 via nuclear factor E2-related factor 2 (Nrf2) translocation into the nucleus and increased the promoter activity of the antioxidant response element (ARE). Moreover, Sulfuretin exposure enhanced the phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase 1/2 (ERK1/2), which are members of the mitogen-activated protein kinase (MAPK) family. Furthermore, cell treatment with a JNK inhibitor (SP600125) and ERK inhibitor (PD98059) reduced Sulfuretin-induced HO-1 expression and decreased its protective effects

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PI3K, platelet, Sulfuretin, stress, mutagenesis, inflammation, inhibit, Nuclear factor-κB, Nuclear factor-kappaB, NF-κB, NFκB, NFkB, NF-kB, oxidative, GSK-3, Inhibitor, monophenolase, diphenolase, Akt, Airway, aggregation, Allergic, (HO)-1, Asthma

Compound Identifiers

PubChem CID

5281295