Sulfuretin

SKU: orb1219040

Description

Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 through the Nrf2/ARE and JNK/ERK signaling pathways.

Key Properties

• CAS Number: 120-05-8
• MW: 270.24
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₀O₅
• SMILES: C1=CC(=C(C=C1/C=C\2/C(=O)C3=C(O2)C=C(C=C3)O)O)O
• Target: Autophagy
• Solubility: DMSO:10 mM

Bioactivity

• In Vivo:
  Sulfuretin inhibits the inflammatory responses by suppressing the NF-κB pathway in type 1 diabetes models. Sulfuretin (40 μg/kg; single intraperitoneal injection 2 h after the last OVA challenge) suppresses ovalbumin (OVA)-induced chemotaxis and airway inflammation. Animal model: Pathogen-free male BALB/c mice (7-8 weeks old). Dosage: 40 μg/kg. Administration: A single intraperitoneal injection was administered 2 h after the last OVA challenge. Result: Suppressed OVA-induced chemotaxis and airway inflammation.
• In Vitro:
  Sulfuretin is one of the main flavonoids produced by Rhus verniciflua. Sulfuretin efficiently inhibits the infiltration of inflammatory cells and attenuates allergic airway inflammation.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Autophagy