Okanin

SKU: orb1220089

Description

Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.Activity-guided fractionation of the EtOH extract of flowers of Bidens bipinnata L. have been furnished five flavonoids, sulfuretin(1), butein(2), 7,8,3 2,4 2-tetrahydroxyflavanone(3), maritimetin(4) and Okanin(5). All of the compounds showed significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect. The evaluation for protective effect of isolated compounds against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells was conducted. Compounds 1, 3, 4 and 5 showed significant protective effects with the EC50 values of 36.1±0.9, 23.3±0.7, 41.0±1.0 and 29.8±1.1 μM, respectively.

Key Properties

• CAS Number: 484-76-4
• MW: 288.3
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₂O₆
• SMILES: C1=CC(=C(C=C1C=CC(=O)C2=C(C(=C(C=C2)O)O)O)O)O
• Target: TLR
• Solubility: In Vitro: DMSO : 16.67 mg/mL (57.83 mM)

Bioactivity

• In Vitro:
  Okanin significantly inhibits LPS-induced TLR4 expression in BV-2 cells. Okanin inhibits the translocation of the NF-κB p65 subunit from the cytosol to the nucleus. Okanin significantly suppresses LPS-induced iNOS expression and also inhibites IL-6 and TNF-α production and mRNA expression in LPS-stimulated BV-2 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

TLR