(S,R,S)-AHPC-Me hydrochloride

SKU: orb1308828

Description

(S,R,S)-AHPC-Me hydrochloride, also known as VHL ligand 2 hydrochloride, is a key component for constructing PROTAC degraders like ARV-771. This potent VHL-recruiting ligand enables the targeted degradation of BET proteins, demonstrating high potency (DC50 <1 nM) in cellular models, including castration-resistant contexts.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1948273-03-7
• MW: 481.05
• Purity: 99.18% (May vary between batches)
• Formula: C₂₃H₃₃ClN₄O₃S
• SMILES: Cl.C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C
• Target: Ligands for E3 Ligase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.16 mM);DMSO:62 mg/mL (128.88 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E3 ligase-recruiting Moiety, E3 ligase Ligand 1, (S,R,S) AHPC Me hydrochloride, (S,R,S)AHPCMe hydrochloride, AHPC-Me Hydrochloride, inhibit, Ligand for E3 Ligase, Ligands for E3 Ligase, LigandforE3Ligase, Inhibitor, VHL, VHL ligand2, VHL ligand-2, VHL ligand 2, VHL ligand 2 Hydrochloride, VHL ligand 2 hydrochloride

Compound Identifiers

PubChem CID

122422950