SR59230A

SKU: orb1309056

Description

SR59230A is a selective β3-adrenergic receptor antagonist, exhibiting potency against β3 (IC50 40 nM) with lower affinity for β1 and β2 receptors. This compound is a valuable pharmacological tool for investigating β3-AR function in metabolic disorders, obesity, and urinary bladder studies, applicable in both in vitro and in vivo research models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 174689-39-5
• MW: 415.48
• Purity: 98.84% (May vary between batches)
• Formula: C₂₃H₂₉NO₆
• SMILES: OC(=O)C(O)=O.CCc1ccccc1OC[C@@H](O)CN[C@H]1CCCc2ccccc12
• Target: Adrenergic Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.81 mM);DMSO:31.88 mg/mL (76.73 mM)

Bioactivity

• Target IC50:
  β1-adrenoceptor:408 nM |β3-adrenoceptor:40 nM |β2-adrenoceptor:648 nM
• In Vitro:
  The specific antagonism of β3-AR by SR59230A inhibits NB growth and tumor progression, by switching from stemness to cell differentiation both in vivo and in vitro through the specific blockade of SK2/S1P2 signaling.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Beta Receptor, adrenergic, Adrenergic Receptor, AdrenergicReceptor, adrenoceptor, hyperthermia, hypothermia, Inhibitor, inhibit, receptor, SR59230A, SR-59230A, β3-adrenoceptor, β3 receptor, β2 receptor, β1 receptor

Compound Identifiers

PubChem CID

9888075