SR59230A hydrochloride

SKU: orb1708455

Description

SR59230A hydrochloride

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1135278-41-9
• MW: 361.91
• Formula: C₂₁H₂₈ClNO₂
• SMILES: N(C[C@@H](COC1=C(CC)C=CC=C1)O)[C@@H]2C=3C(CCC2)=CC=CC3.Cl
• Target: Adrenergic Receptor
• Solubility: H2O:1 mg/mL (2.76 mM);DMSO:200 mg/mL (552.62 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.82 mM)

Bioactivity

• Target IC50:
  β2-adrenoceptor:648 nM |β3-adrenoceptor:40 nM |β1-adrenoceptor:408 nM
• In Vivo:
  MDMA (20 mg/kg) caused a slow rise in body temperature, reaching a maximum temperature increase of 1.8°C at 130 min post-injection. SR59230A hydrochloride (0.5 mg/kg) was able to slightly but significantly alleviate the slow rise in body temperature induced by MDMA. SR59230A hydrochloride (5 mg/kg) exhibited a significant and pronounced early hypothermic response to MDMA.
  Read more...
• In Vitro:
  SR59230A hydrochloride (100 nM-50 μM; 24 hours) can reduce cell viability in a dose-dependent manner in Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Adrenergic Receptor, AdrenergicReceptor, SR59230A HCl, SR59230A Hydrochloride, SR-59230A hydrochloride, β2 receptor, β1 receptor, β3-adrenergic receptor, β3 receptor

Compound Identifiers

PubChem CID

24978529